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Creatinine is the waste that is continuously produced during the muscle break down in the kidney. The kidney tends to adsorb zero Creatinine into the blood and remove all of it into the urine. Creatinine Clearance or CrCl is a clinical rule (measured in mL/min) that is used to measure renal function. In simple words, it is used to measure the kidney’s ability to handle creatinine.

As creatinine is continuously produced in the blood and removal of this is necessary, creatinine clearance is the rate at which the kidney tends to remove creatinine from the blood plasma and this helps to measure the GFR (glomerular filtration rate) which is the rate of flow of blood in kidneys.

Normal creatinine clearance in adults is: 95 - 160 mL/min

CrCl or GFR are used with patients suffering from renal disease or when careful dosing of metabolized drug is needed.

You can calculate creatinine clearance CrCl by using our calculator. CrCl score is then used to calculate the GFR of patients. GFR can be calculated by Cockcroft-Gault equation easily but apart from this equation you can use the following formulas as well:

- CKD-EPI Creatinine-Cystatin Equation
- CKD-EPI Cystatin C Equation
- CKD-EPI Creatinine Equation
- MDRD Study Equation

CrCl is directly related to GFR, so the first thing to know is how to calculate creatinine clearance.

This formula is widely used to calculate creatinine clearance in a person easily. This simple formula uses serum creatinine (SCR) and takes the weight (in kg) of the patient into account to calculate the estimated CrCl in mL/min.

The creatinine clearance** **formula that is used for adult ≥18 years is:

CrCl = (140 - age) * weight * sex / (72 * sCr)

This creatinine clearance equation is for both men and women but for women requires multiplication of with 0.85 and 1 for men.

Creatinine clearance can also be calculated using serum (sCr), urine creatinine (uCr) and urine volume.

The CrCl equation is:

dCrCl = uCr * urine volume / (sCr * urine collection duration)

This formula is reliable but not used most of the times as urine sample is not available 24 hours. The person has to fill a jar of urine and keep it for 24 hours then they can bring the sample for tests.

Calculating CrCl manually requires some specific creatinine correction tests and is the time taken as well. Our creatinine correction calculator is not only just time saver but precise as well.

The requirement to use our calculator are:

- Gender
- Precise age in years
- Percentage of serum creatinine
- Weight in kg

Every field available in the above calculator needs to be filled. After inserting sufficient data, just click on the “calculate” button and the results will show up in seconds.

The results include:

- The CC score
- CKD stage according to the score

CKD is the classification of kidney disease. Each stage shows the severity of the disease which increases from stage 1 to stage 5. Here are the stages of CKD with GFR values:

- Stage 1: low kidney damage with normal or slight increased GFR (>90 mL/min/1.73 m
^{2}) - Stage 2: Minor decrease in GFR (60-89 mL/min/1.73 m
^{2}) - Stage 3a: Adequate decrease in GFR (45-59 mL/min/1.73 m
^{2}) - Stage 3b: Moderate decrease in GFR (30-44 mL/min/1.73 m
^{2}) - Stage 4: Severe decrease in GFR (15-29 mL/min/1.73 m
^{2}) - Stage 5: Kidney failure (GFR < 15 mL/min/1.73 m
^{2}or require dialysis)

Normal creatinine clearance in both men and women is different:

- For healthy women 88–128 mL/min
- For healthy men 97–137 mL/min

Here is a creatinine levels chart that shows normal to high ranges of creatinine in blood in mg/mmol: